Pre- & Post-Synaptic
Laugh, cry, enjoy and be free to live. Do not let fine lines #chooseyourexpression. Munapsys™ is a botulinum toxin-like peptide obtained by in silico design in collaboration with experts in neuroscience.
It is the first cosmetic ingredient able to act both in the pre- and post-synaptic pathways of muscle contraction and in a new SNARE protein (Munc-18). Munc-18 binds to syntaxin allowing the assembly of the SNARE complex. Pre-synaptic: Munapsys™ competes with Munc-18 for its position in syntaxin, obstructing SNARE complex assembly and the release of the acetylcholine (ACh) neurotransmitter into the synapse. Post-synaptic: ACh activates clustered AChR, inducing a depolarization and opening Ca2+ channels allowing actomyosin cross-bridge and sliding for muscle contraction. Munapsys™ modulates AChR clustering, depolarization, Ca2+ mobilization, and actomyosin cross-bridge and sliding.
Munapsys™ mechanism is a real upgrade in the expression lines field, with proven efficacy compared with a benchmark combination even at a lower dose. Let yourself enjoy from a new generation of botulinum-like ingredients. A safe, real beauty filter.
Before & After
Up to 37.6% less depth of the biggest wrinkle in 7 days
+31% volunteers showing efficacy in Rt with 3% Munapsys™ than with 5% benchmark at 14 days
Up to 16.7% happier smile (lifting of commissures)
|T7 days (3% Munapsys™)
–25.5% average roughness (Ra)
|T14 days (3% Munapsys™)
–10.4% average roughness (Ra)
+16.7% happier smile