• Pre- & Post-Synaptic
  • Expression Wrinkles
  • Smiling



Laugh, cry, enjoy and be free to live. Do not let fine lines #chooseyourexpression. Munapsys™ is a botulinum toxin-like peptide obtained by in silico design in collaboration with experts in neuroscience.

It is the first cosmetic ingredient able to act both in the pre- and post-synaptic pathways of muscle contraction and in a new SNARE protein (Munc-18). Munc-18 binds to syntaxin allowing the assembly of the SNARE complex. Pre-synaptic: Munapsys™ competes with Munc-18 for its position in syntaxin, obstructing SNARE complex assembly and the release of the acetylcholine (ACh) neurotransmitter into the synapse. Post-synaptic: ACh activates clustered AChR, inducing a depolarization and opening Ca2+ channels allowing actomyosin cross-bridge and sliding for muscle contraction. Munapsys™ modulates AChR clustering, depolarization, Ca2+ mobilization, and actomyosin cross-bridge and sliding.

Munapsys™ mechanism is a real upgrade in the expression lines field, with proven efficacy compared with a benchmark combination even at a lower dose. Let yourself enjoy from a new generation of botulinum-like ingredients. A safe, real beauty filter.


Before & After

Up to 37.6% less depth of the biggest wrinkle in 7 days

+31% volunteers showing efficacy in Rt with 3% Munapsys™ than with 5% benchmark at 14 days

Up to 16.7% happier smile (lifting of commissures)


T7 days (3% Munapsys™)

–25.5% average roughness (Ra)
–14.2% average relief (Rz)
–16.6% max relief height (Rt)
–25.5% maximum wrinkle depth


T14 days (3% Munapsys™)

–10.4% average roughness (Ra)
–10.3% average relief (Rz)
–13.6% max relief height (Rt)
–21.1% wrinkles volume



+16.7% happier smile
(lifting of commissures)

Product Video