• Cyclic petide
  • Wrinkle’s Daily Cycle
  • Refolding proteins


Organizing skintropy

The circle is a simple but perfect geometric conformation that helps to maintain order. Much like a circle, a cyclic peptide does not have a beginning nor an end, making it less prone to enzymatic degradation and hence more efficient.

As we age, skintropy, the chaos or disorder in our skin, increases. Hence, there is an impairment of proper protein folding ending in stress in the cell’s endoplasmic reticulum. Skintropy increases during the day due to gravity and our facial expressions until it reaches a maximum level in the evening. This leads to a fluctuation of wrinkles we call the Wrinkle’s Daily Cycle (WDC). Consequently, evening wrinkles are more pronounced than in the morning. The cycle continues at night when our skin is repaired and dermal fluids are redistributed.

Poptide™ is a cyclic peptide that organizes skintropy by raising BiP and calreticulin (folding optimizers) in the endoplasmic reticulum improving protein folding. Poptide™ acts on the WDC by reducing morning & evening wrinkles, redefining the wrinkle’s daily fluctuation

Make your skin pop the whole day with Poptide™, the cyclic peptide that restores the order to the skin.

Product Applications

-33% reduction of the gap between morning & evening depth after 28 days

-10% less wrinkle’s depth both in the morning and evening

Up to -14% less wrinkle’s volume at 28 days both in the morning and evening

Up to +12% more evening skin thickness

T0 days T28 days


-15% depth

-8% volume


-13% depth

-8% volume