• Dermochronology
  • Solar scars guardian
  • Redefining dermis

Timlog™

Redefining the past

Just as the skin, trees have memory, their life story can be read in their rings. Tree rings record not only age (dendrochronology), but also each season & climate experience (wet, hot, early frosts, sunlight, etc). Just as trees need sunlight, skin does too, but an excess of it can lead to premature aging which alters skin’s dermochronology

A photoaged skin (scar-like dermis) is characterized by a high content of MMPs which degrade the extracellular matrix and alter collagen density & organization (synthesis & deposition). The guardians against MMPs are TIMPs, which are specific inhibitors that bind to them 

Timlog™ is a biomimetic TIMP-2 (Tissue inhibitor of metalloproteinases) produced in Wild plants as biofactories technology through vertical farming. TIMP-2 is an inhibitor of all MMPs (specifically of MMP-2). Additionally, it increases fibromodulin which has an important role in organizing the ECM by binding to collagen, resulting in delay of fibril formation and the formation of thinner fibers

Timlog™ acts as a guardian for skin’s dermochronology, repairing dermal solar scars redefining the past

Before & After

Non UV-exposed

 UV-exposed + Timlog™ UV-exposed

 

+127% fibromodulin vs basal, which is key in scarless repair

+8% skin isotropy in 7 days
T0 days
 T28 days
+6.9% isotropy

 

+2% & +6% fibers density in the dermis after 28 days
T0 days

 T28 days
+37% fibers density

 

Up to -29% less Ra max after 28 days